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Keyword Search Criteria: dose finding returned 15 record(s)
Monday, 07/30/2018
Dose Finding Methods Using Two Endpoints in Early Clinical Studies
Kyounghwa Bae, Janssen Research & Development, LLC; Zhentao Tong, North Carolina State University ; Vladimir Dragalin, Janssen R&D


A Bayesian Logistic Model with Covariate to Identify Optimal Dose for Heterogeneous Population in Phase I Oncology Trial
Xin Wei, Celgene Corporation; Michael Branson, celgene corporation
8:50 AM

A Bayesian Phase I/II Trial Design for Immunotherapy
Suyu Liu, MD Anderson Cancer Center; Beibei Guo, Louisiana State University; Ying Yuan, University of Texas M.D. Anderson Cancer Center
10:35 AM

Dose Finding Methods Using Two Endpoints in Early Clinical Studies
Kyounghwa Bae, Janssen Research & Development, LLC; Zhentao Tong, North Carolina State University ; Vladimir Dragalin, Janssen R&D
11:55 AM

Improvements to the Escalation with Overdose Control Design and a Comparison with the Restricted Continual Reassessment Method
Lingyun Ji, University of Southern California; Richard Sposto, University of Southern California; Juan Pablo Lewinger, University of Southern California; Mark Krailo, University of Southern California; David Conti, University of Southern California; Susan Groshen, University of Southern California; Shahab Asgharzadeh, University of Southern California
3:00 PM

Tuesday, 07/31/2018
Improvements to the Escalation with Overdose Control Design and a Comparison with the Restricted Continual Reassessment Method
Lingyun Ji, University of Southern California; Richard Sposto, University of Southern California; Juan Pablo Lewinger, University of Southern California; Mark Krailo, University of Southern California; David Conti, University of Southern California; Susan Groshen, University of Southern California; Shahab Asgharzadeh, University of Southern California


STEPDOWN TESTING PROCEDURES for DOSE FINDING STUDY with ADAPTIVE DESIGN
Gang Jia, Merck & Co.


STEPDOWN TESTING PROCEDURES for DOSE FINDING STUDY with ADAPTIVE DESIGN
Gang Jia, Merck & Co.
8:55 AM

Reversals in Early Phase Dose Finding Trials
Bethany Horton, University of Virginia; John O'Quigley, Universit'e Pierre et Marie Curie, ; Mark Conaway, University of Virginia
10:35 AM

Dose Finding Model Selection in Oncology Combination Therapy
Lixia Pei, Janssen Pharmaceuticals ; Yichen Guo, Harvard University; Kevin Liu, Janssen Pharmaceuticals
2:20 PM

Wednesday, 08/01/2018
Considerations on MCPMod-Type Methods for Proof of Concept in Multi-Armed Studies
Tobias Mielke, Janssen-Cilag GmbH
9:05 AM

Novel Model-Assisted Designs for Phase I Drug Combination Trials
Ruitao Lin, MD Anderson Cancer Center
10:35 AM

Adaptive Dose Finding in Oncology Phase I-II Studies with Consideration of Tolerability and Efficacy
Rachael Liu, Takeda Pharmaceuticals ; Ling Wang, Takeda; David Sinclair, Google; Jianchang Lin, Takeda Pharmaceuticals
11:35 AM

Thursday, 08/02/2018
Adaptive Bayesian Interval-Based Oncology Dose Finding Design with Quasi-Continuous Toxicity Model
Dan Zhao, University of Illinois at Chicago; Jian Zhu, Takeda; Eric Westin, ImmunoGen; Ling Wang, Takeda
10:50 AM

BOIN-ET: Bayesian Optimal Interval Design for Dose Finding Based on Both Efficacy and Toxicity Outcomes
Kentaro Takeda, Astellas Pharma Global Development, Inc.; Masataka Taguri, Yokohama City University; Satoshi Morita, Kyoto University
12:05 PM